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BioTrove Raises $5.25 Million in Venture Financing

Two New Members Appointed to Board of Directors

Cambridge, MA, November 6, 2002—BioTrove, Inc. announced today that it raised $5.25M in a second round of private equity financing, from a syndicate of new investors, to expand the company’s two core platforms that improve the efficiency and productivity of drug discovery. The round was led by Catalyst Health and Technology Partners, and includes investments from CB Health Ventures, Zero Stage Capital and BioFrontier Partners. In addition, the company appointed two new directors, Mr. Joshua S. Phillips, a managing director at Catalyst Health and Technology Partners, and Dr. Enrico Petrillo, a general partner at CB Health Ventures LLC.

BioTrove is addressing the demanding pressure in drug discovery to screen more targets, find high quality leads, and develop more effective assays through the development of its proprietary Living Chip™ and Lab-on-a-Tape™ technologies. Consisting of a high-density array of through-holes in a planar substrate, the Living Chip enables the rapid initiation and parallel analysis of up to 24, 576 samples in nanoliter-scale reaction volumes, far exceeding the throughput capacity of current technologies. The Lab-on-a-Tape system combines nanoliter volumes with automated high throughput analysis for rapid screening and assay development. BioTrove has achieved its first commercial collaboration with Pfizer, Inc. in an agreement involving Lab-on-a-Tape.

“This financing is a strong endorsement of the substantial progress we have made in developing our core nanofluidic platforms and validates the potential value our technologies bring to customers,” said Colin J.H. Brenan, Ph.D., President and Chief Executive Officer of BioTrove. “These funds will significantly strengthen our ability to address market opportunities in drug discovery, genomic screening and protein engineering. Having assembled such a strong group of investors, we can now leverage the experience and resources needed to further build the company.”

“We are pleased to be a part of the BioTrove team as it commercializes two exciting nanofluidic platforms that will bring dramatic benefits to the drug discovery process," said Joshua S. Phillips of Catalyst Health and Technology Partners. He added, "These technologies will significantly reduce assay development time, reagent costs, screening time and expense, enabling more rapid discovery.”

“We believe BioTrove’s nanofluidic technology is a powerful new approach as an integrated platform for drug discovery,” said Dr. Enrico Petrillo of CB Health Ventures LLC. He added, “We are proud to support BioTrove as the company moves into the next phase of corporate development and commercialization of its unique systems, further positioning BioTrove as a leader in the field of nanofluidic drug discovery and development.”

Joshua Phillips brings to BioTrove’s Board considerable experience and multifaceted perspectives in building businesses. In addition to venture capital, Mr. Phillip’s career has included strategy consulting, management, and engineering at Pratt and Whitney Aircraft, Russelectric, Inc. and the Lucas Group. Josh's investment interests at Catalyst span both the life sciences and technology markets, with particular interest in drug discovery tools and enterprise software. Mr. Phillip’s previous investments at Catalyst include Novazyme Pharmaceuticals, Inc. and Castel, Inc. Mr. Phillips earned his BE in Electrical Engineering and Mathematics from Vanderbilt University and his MBA from Harvard Business School.

Dr. Enrico Petrillo is a General Partner of CB Health Ventures, LLC and brings to BioTrove’s Board of Directors a strong background in strategic management, venture capital and private equity financing for pharmaceutical, healthcare and biotechnology industries. Prior to joining CB Health Ventures, he served as Senior Consultant from 1984-1996 and as Partner and Head of Healthcare Commercialization from 1991-1996 at Fletcher Spaght. He is presently an Adjunct Assistant Professor of Medicine at Boston University School of Medicine and Boston Medical Center. Dr. Petrillo serves as a director on the boards of U.S. Genomics, Inc., Spherics, Inc., and Morphotek, Inc. In addition, he was a venture investor in eBenX (NASDAQ: EBNX), and also contributed to Exact Sciences (NASDAQ: EXAS) and Quovadex (formerly XCare.net) (NASDAQ: QVDX) as a venture investor and board member. Dr. Petrillo received his BS and MD degrees from Tufts University and its School of Medicine.

About BioTrove

BioTrove Inc. is a privately held biotechnology company focused on leveraging revolutionary micro- and nano-scale engineering solutions to overcome current bottlenecks in pharmaceutical and biotechnology drug discovery. BioTrove has two core nanofluidic platforms: the Living Chip™ and the Lab-on-a-Tape™. BioTrove offers integrated nanoliter storage and ultra high throughput screening solutions for drug discovery, genetic engineering, diagnostics and materials science.

About Catalyst Health and Technology Partners

Catalyst Health and Technology Partners is a venture capital firm dedicated to helping promising early-stage health care, life science, and technology ventures grow. The firm focuses on investment opportunities including drug discovery, medical devices, biopharmaceuticals, drug delivery, convergence and software.

About CB Healthcare Fund

CB Health Ventures manages $150 million of private equity funds focused on investment opportunities in life sciences, medical devices, healthcare services and medical information technology.

About Zero Stage Capital

Founded in 1981, Zero Stage Capital, a Cambridge, MA-based venture capital firm with offices in Connecticut and Rhode Island, invests in emerging growth companies in the information technology, communications, life sciences, and energy technology sectors. Zero Stage Capital manages seven balanced and diversified funds that provide support for businesses at every stage of development. The firm has over $400 million in capital under management and has invested in more than 100 companies.

About BioFrontier Partners Inc.

BioFrontier Partners, Inc. is a leading Japanese venture capital firm focused on life sciences with more than $100 million under management. Since its founding in 1999, BioFrontier Partners has invested in start-up companies in the following areas: biotechnology, pharmaceuticals, genomics, proteomics, agricultural biotechnology, natural products, medical devices, gene therapy and drug discovery. BioFrontier Partners is headquartered in Tokyo and has a U.S. office in San Diego, CA.

For more information contact:

Dr. Colin Brenan,
President and Chief Executive Officer, BioTrove Inc.

Karla MacDonald,
Vice President, Feinstein Kean Healthcare
(617) 577-8110

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